Table 5.
Impact of MGD on Chromosomal Gene Expression in Human Meibomian Glands
| Chromosome | MGD Genes ↑ | Control Genes ↑ | MGD z-Score | Control z-Score |
|---|---|---|---|---|
| 14 | 12 | 8 | 3.26 | 1.16 |
| 1 | 25 | 19 | 2.94 | 0.86 |
| 12 | 13 | 5 | 2.03 | −1.17 |
| 8 | 1 | 8 | −2.16 | 0.44 |
| 5 | 2 | 4 | −2.20 | −1.67 |
| 7 | 1 | 12 | −2.35 | 1.57 |
| 13 | 1 | 9 | −1.39 | 2.61 |
| 17 | 9 | 14 | 0.75 | 2.33 |
Chromosomes with the highest and lowest z-scores were selected after the analysis of log-transformed microarray data. A z-score is a statistical rating of the relative expression of genes and depicts how much they are over- or underrepresented in a given gene list.54 Positive z-scores reflect a greater number of genes meeting the criterion than is expected by chance, whereas negative z-scores represent fewer genes meeting the criterion than expected by chance.54 The z-scores with values >2.0 or < −2.0 are significant and are highlighted in bold. MGD Genes ↑, number of genes upregulated in MGD tissues; Control Genes ↑, number of genes upregulated in control tissues; z-score, specific score for the upregulated genes in the MGD and control tissues. High and low values for the MGD and control groups are highlighted in bold.