Fig. 4.

Binding of compound 2 in the active site of FAAH. (A) Electron density contoured at 1σ from a 2Fo-Fc map for compound 2, Ser241 and Ser217 of the catalytic triad are shown as a blue mesh. Compound 2 is shown in sticks with carbon in magenta, and the catalytic residues are in sticks with carbon in green. The protein is shown in ribbon representation. (B) Overall binding of compound 2 in the active site, with compound 1 (with carbon in yellow) overlaid. The protein is shown in ribbons, and the red dotted van der Waals surfaces highlight the different binding sites of the carbonyl oxygen in the two compounds.