Table 1.
TDI kernel genomes.
| Organisma | Transcriptsb | Modeled targetsc | Similard | Exacte |
|---|---|---|---|---|
| Cryptosporidium hominis | 3,886 | 666 | 20 | 13 |
| Cryptosporidium parvum | 3,806 | 742 | 24 | 13 |
|
| ||||
| Leishmania major | 8,274 | 1,409 | 43 | 20 |
|
| ||||
| Mycobacterium leprae | 1,605 | 893 | 25 | 6 |
|
| ||||
| Mycobacterium tuberculosis | 3,991 | 1,608 | 30 | 10 |
|
| ||||
| Plasmodium falciparum | 5,363 | 818 | 28 | 13 |
|
| ||||
| Plasmodium vivax | 5,342 | 822 | 24 | 13 |
|
| ||||
| Toxoplasma gondii | 7,793 | 300 | 13 | 6 |
|
| ||||
| Trypanosoma cruzi | 19,607 | 3,070 | 51 | 28 |
|
| ||||
| Trypanosoma brucei | 9,210 | 1,386 | 39 | 21 |
|
| ||||
| Total | 68,877 | 11,714 | 297 | 143 |
a
Organisms in bold are included in the WHO Tropical Disease portfolio.
b
Number of transcripts in each genome.
c
Number of targets with at least one domain accurately modeled (i.e., MODPIPE quality score of at least 1.0).
d
Number of modeled targets with at least one predicted binding site for a molecule with a Tanimoto score9 of at least 0.9 to a drug in DrugBank10.
e
Number of modeled targets with at least one predicted binding site for a molecule in DrugBank.