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. 2011 May 5;6(5):e19297. doi: 10.1371/journal.pone.0019297

Figure 7. Model for LMO3 and HEN2 cooperation in transcriptional regulation of Mash1 in Neuroblastoma.

Figure 7

HES1 binds to HES1 binding sites and E-box on Mash1 promoter and represses Mash1 transcription. LMO3 inhibits recruitment of HES1 onto HES1-binding sites and E-box on Mash1 promoter by forming complex with HES1. HEN2 interferes with recruitment of HES1 onto HES1-binding sites and E-box on Mash1 promoter by forming complex with HES1 and competing with HES1 in binding to these sites. LMO3 promotes recruitment of HEN2 onto HES1-binding sites and E-box on Mash1 promoter by forming complex with HEN2 but inhibits negative effects of HEN2 on Mash1 promoter. Thereby expression of Mash1 is up-regulated.