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. 2011 May 5;6(5):e19437. doi: 10.1371/journal.pone.0019437

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Prochnow et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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3A–B show the outcome of measurements of the stress related plasma hormones Adrenocorticotrophin (ACTH) and Corticosterone (CORT) in the differentially treated groups of animals. The blood was collected from the trunk after decapitation of the animals. Note, that a handled group (0-C) which was trained to visit the guillotine voluntarily after training was used for reference. 3A, Holm-Sidak comparison of the ACTH levels revealed significantly increased values in cage controls (CC), the SAR 0 W/kg (Sham), 2 W/kg (2 W/kg) and 10 W/kg (10 W/kg) treated animals when compared with the 0-C group. Furthermore all exposure setup treated animals showed strongly increased ACTH levels when compared to the CC group, indicating a high degree of procedure related stress. Comparable findings were made in regarding the plasma CORT levels in 3B. The result clearly underlines the handling and procedure related stress component.