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. 2011 May 5;6(5):e19562. doi: 10.1371/journal.pone.0019562

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Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The value of each amplified fragment covering HCV genome was considered as an independent data point. Panel A, synonymous nucleotide diversity (π_S). The distribution of π_S differed significantly across the estimated decades of infection (p<0.001). Panel B, non-synonymous nucleotide diversity (π_N). The distribution of π_N differed significantly across the estimated decades of infection (p = 0.021). Panel C, π_N/π_S ratio. The distribution of π_N/π_S ratio differed significantly across the estimated decades of infection (p = 0.006). Panel D, π_N/π_S ratio. The π_N/π_S ratio was significantly negatively correlated to the estimated year of HCV infection (r = −0.300, p = 0.003).