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. 2011 May 5;6(5):e19562. doi: 10.1371/journal.pone.0019562

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Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The value of each amplified fragment covering HCV genome was considered as an independent data point. Panel A, synonymous nucleotide diversity (π_S). Panel B, non-synonymous nucleotide diversity (π_N). Panel C, π_N/π_S ratio. None of the comparisons showed significant difference between the early and late time points for the categories of participants with consistent mild, mild to severe, and consistent severe disease.