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. 2011 May 5;6(5):e19562. doi: 10.1371/journal.pone.0019562

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Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The value of each amplified fragment covering HCV genome was considered as an independent data point. Panel A, synonymous nucleotide divergence (d_S). Panel B, non-synonymous nucleotide divergence (d_N). Panel C, synonymous nucleotide divergence per year (d_S/year). Panel D, non-synonymous nucleotide divergence per year (d_N/year). A significant difference of d_N/year was found between the participants with consistent mild disease and those with mild to severe disease (p = 0.008). Panel E, d_N/d_S ratio. A significant difference of d_N/d_S ratio was found between the participants with consistent mild disease and those with mild to severe disease (p = 0.003).