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. 2011 May 5;6(5):e19562. doi: 10.1371/journal.pone.0019562

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Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The Shannon entropy was calculated at single time point based on the amino acid sequences of individual genes. Panel A, the intra-time-point Shannon entropy of each gene compared according to the estimated year of infection. A significant correlation between the Shannon entropy and the estimated year of infection was found for E2, NS2, and NS5A genes. Panel B, the intra-time-point Shannon entropy of each gene compared according to the mild and severe disease status. No significant difference was found for the genes between the two disease groups.