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. 2011 May 5;6(5):e19562. doi: 10.1371/journal.pone.0019562

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Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The Shannon entropy was calculated between the early and late time points based on the amino acid sequences of individual genes. Panel A, the inter-time-point Shannon entropy of each gene compared between the participants with mild or severe outcomes. No significant difference was found for the genes between the two disease groups. Panel B, yearly change of the inter-time-point Shannon entropy compared between the participants with mild or severe outcomes. Significant differences were found for the genes of p7, NS2, NS3, and NS5B between the two disease groups.