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Inhibition of the PI3K-Akt pathway reduces ASCL1 and CgA. Western blot analysis showed a decrease in levels of ASCL1, a proneuroendocrine transcription factor, and chromogranin A (CgA), a marker of hormonal secretion. Inhibition of the PI3K-Akt pathway leads to a decrease in the NE phenotypte and hormonal secretion
