Table 2.
Association between baseline concentrations of well arsenic (µg/L) and mortality from disease of circulatory system during follow-up
| Hazard ratio (95% CI) per 1 SD (115 µg/L) increase | Hazard ratio (95% CI) by mean (range) baseline concentrations | P for trend* | ||||
|---|---|---|---|---|---|---|
| 3.7 (0.1-12.0) | 35.9 (12.1-62.0) | 102.5 (62.1-148.0) | 265.7 (148.1-864.0) | |||
| Person years of follow-up | 77 252 | 20 064 | 19 109 | 18 699 | 19 380 | — |
| Disease of circulatory system | ||||||
| No of deaths | 198 | 43 | 51 | 41 | 63 | — |
| Model 1† | 1.08 (0.96 to 1.22) | 1.00 | 1.35 (0.91 to 2.00) | 1.17 (0.76 to 1.79) | 1.47 (0.99 to 2.18) | 0.2153 |
| Model 2‡ | 1.11 (0.97 to 1.26) | 1.00 | 1.21 (0.80 to 1.84) | 1.24 (0.80 to 1.93) | 1.46 (0.96 to 2.20) | 0.1340 |
| Ischaemic heart disease and other forms of heart disease | ||||||
| No of deaths | 104 | 21 | 24 | 21 | 38 | — |
| Model 1† | 1.23 (1.05 to 1.43) | 1.00 | 1.29 (0.71 to 2.34) | 1.20 (0.65 to 2.22) | 1.84 (1.06 to 3.17) | 0.0072 |
| Model 2‡ | 1.29 (1.10 to 1.52) | 1.00 | 1.22 (0.65 to 2.32) | 1.35 (0.71 to 2.57) | 1.92 (1.07 to 3.43) | 0.0019 |
| Ischaemic heart disease | ||||||
| No of deaths | 71 | 14 | 16 | 15 | 26 | — |
| Model 1† | 1.19 (1.00 to 1.42) | 1.00 | 1.31 (0.63 to 2.71) | 1.31 (0.63 to 2.72) | 1.89 (1.00 to 3.60) | 0.0479 |
| Model 2‡ | 1.25 (1.03 to 1.52) | 1.00 | 1.22 (0.56 to 2.65) | 1.49 (0.70 to 3.19) | 1.94 (0.99 to 3.84) | 0.0294 |
| Cerebrovascular disease | ||||||
| No of deaths | 85 | 19 | 26 | 18 | 22 | — |
| Model 1† | 0.90 (0.73 to 1.11) | 1.00 | 1.56 (0.88 to 2.79) | 1.20 (0.64 to 2.26) | 1.15 (0.59 to 2.22) | 0.3099 |
| Model 2‡ | 0.89 (0.71 to 1.13) | 1.00 | 1.35 (0.75 to 2.43) | 1.20 (0.63 to 2.27) | 1.07 (0.54 to 2.12) | 0.3427 |
*Estimated with arsenic exposure variable as continuous variable in model.
†Adjusted for sex and baseline age (years).
‡Adjusted for sex and baseline age (years), BMI, smoking status (never, past, current), educational attainment (years), and changes in arsenic concentration adjusted for urinary creatinine (µg per g of creatinine) between visits.