Table 1.

Classification scheme of biological markers evaluated in the comprehensive review

Steroid receptors	Estrogen receptor, progesterone receptor, and androgen receptor
Proliferation marker	Ki-67
Cell cycle regulation and apoptotic markers	cyclin D1, cyclin A, cyclin E, p16, p21, p27, p53, Bcl-2, Bax, Survivin, c-myc, and retinoblastoma
Angiogenesis related proteins	Vascular endothelial growth factor and heparanase-1
Epidermal growth factor receptor family	HER1, HER2, HER3, and HER4
Extracellular matrix related proteins	CD10
	Secreted protein acidic and rich in cysteine
Other biological marker	COX-2