Table 8.

Expression rate of COX-2 in DCIS

Biomarker	First author and reference	Year	No. of samples	Expression rate, %	Definition of positivity
	Tan 63	2004	51	80	On a 9-point scale, 0 was considered to be nil; 1-3 was considered to be mild; 4-6 was considered to moderate; 7-9 was considered to be strong. Only unequivocal cytoplasmic staining was regarded as positive.
	Boland 19	2004	187	67	On a 3-point scale, a score of at least 2. Expression was based on the extent and intensity of epithelial cell staining.
	Perrone 20	2005	49	87.8	On a 12-point scale for immunoreactivity, an immunohistochemistry score of 9-12 was considered strong, 5-8 was considered moderate, 1-4 was considered weak, and 0 was considered negative.
	Gauthier 62	2005	30	60.7	No cut-off value was mentioned in the paper.
	Barnes 54	2006	161	72	Score of at least 2.
	Gauthier 45	2007	70	55.7	Allred score of at least 2.
	Kulkarni 21	2008	69	45.8	Cytoplasmic granular staining in more than 10% of tumor cells.
	Bundred 30	2010	90	58	A minimum of 500 cells was investigated across randomly selected areas of DCIS at a magnification of x 400 using a grid graticule and cell counter for each of the two sections. All cases were ER-positive DCIS.
	de la Torre 64	2010	52	53	On a 3-point scale, a score of at least 2.
	Kerlikowske 24	2010	329	44.4	On a 3-point scale, a score of at least 2.