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. 2011 May 4;2:262–270. doi: 10.7150/jca.2.262

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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The Abrams OSA cell line produces an aggressive tumor in the Rag1 mouse. 1. Heterologous tumor growth of Abrams cells in Rag1 mouse. Grossly, the tumor measures 13.4 mm long x 8.8 mm wide 10 wk post injection. 2. Histopathology of heterologous Abrams skin tumor 10 wk post xenografting via subcutaneous injection (Hematoxylin and Eosin). Arrow denotes a mitotic figure. 3. Heterologous Abrams cell tumor metastasis to lung (Hematoxylin and Eosin). Inset of lung metastasis at higher power. 4. Abrams cells stain positively for alkaline phosphatase with hematoxylin counterstain.