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Implication of Stem Cells in Liver Development and Hepatic Tumorigenesis. Normal hepatic stem cells are characterized by their ability to self-renew and differentiate, which leads to formation of a normal liver tissues. Oncogenic mutations in normal stem/progenitor cells or even in differentiated cells enhance or endow the cells with self-renewal capability. Consequently, these cells function as cancer stem cells and contribute to the formation of bulk tumors.
