Table 1.
List of gene set regulated by NGF in HMC-1 (V560G c-Kit) cells.
| Symbol | Gene accession ID | Description | Fold change |
|---|---|---|---|
| CYTOKINES | |||
| CLCF1 | NM_013246 | cardiotrophin-like cytokine factor 1 | 2.6 |
| FASLG | NM_000639 | Fas ligand (TNF superfamily, member 6) | 3.0 |
| IL1B | NM_000576 | interleukin 1, beta | 2.2 |
| LIF | NM_002309 | leukemia inhibitory factor (cholinergic differentiation factor) | 2.4 |
| LTB | NM_002341 | lymphotoxin beta (TNF superfamily, member 3) | 2.2 |
| GROWTH FACTOR | |||
| GDF15 | NM_004864 | growth differentiation factor 15 | 3.2 |
| ENZYMES | |||
| ARL5B | NM_178815 | ADP-ribosylation factor-like 5B | 3.1 |
| B3GALNT2 | NM_152490 | beta-1,3-N-acetylgalactosaminyltransferase 2 | 2.8 |
| CYCS | NM_018947 | cytochrome c, somatic | 2.6 |
| GALNT4 | NM_003774 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) | 3.2 |
| GEM | NM_005261 | GTP binding protein overexpressed in skeletal muscle | 2.9 |
| LFNG | NM_001040167 | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.5 |
| PAICS | NM_006452 | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 2.9 |
| RRAD | NM_004165 | Ras-related associated with diabetes | 2.5 |
| TEP1 | NM_007110 | telomerase-associated protein 1 | 3.8 |
| UBE2E1 | NM_152653 | ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) | 4.2 |
| KINASES | |||
| AATK | AK131529 | cDNA FLJ16758 fis, clone BRACE3038687, moderately similar to Homo sapiens apoptosis-associated tyrosine kinase (AATK) | 2.5 |
| PANK2 | AL713654 | Homo sapiens mRNA; cDNA DKFZp547J0513 (from clone DKFZp547J0513). | 2.2 |
| PLK3 | NM_004073 | polo-like kinase 3 (Drosophila) | 5.1 |
| PRKAR2A | NM_004157 | protein kinase, cAMP-dependent, regulatory, type II, alpha | 3.4 |
| SGK1 | NM_005627 | serum/glucocorticoid regulated kinase | 2.3 |
| TRIB1 | NM_025195 | tribbles homolog 1 (Drosophila) | 2.8 |
| LIGAND DEPENDENT NUCLEAR RECEPTOR | |||
| NR4A1 | NM_002135 | nuclear receptor subfamily 4, group A, member 1 | 4.7 |
| NR4A2 | NM_006186 | nuclear receptor subfamily 4, group A, member 2 | 2.8 |
| NR4A3 | NM_006981 | nuclear receptor subfamily 4, group A, member 3 | 2.6 |
| G-PROTEIN COUPLED RECEPTORS | |||
| CXCR4 | NM_001008540 | chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 1 | 2.0 |
| HRH1 | NM_000861 | histamine receptor H1 | 2.1 |
| PEPTIDASE | |||
| CTSZ | NM_001336 | cathepsin Z | 3.0 |
| TRANSCRIPTON REGULATOR | |||
| ACTN2 | NM_001103 | actinin, alpha 2 | 2.5 |
| ARNTL2 | NM_020183 | aryl hydrocarbon receptor nuclear translocator-like 2 | 2.2 |
| ATF3 | NM_004024 | Homo sapiens activating transcription factor 3 (ATF3), transcript variant 2 | 2.9 |
| AXUD1 | NM_033027 | AXIN1 up-regulated 1 (AXUD1) | 2.5 |
| EGR1 | NM_001964 | early growth response 1 | 29.6 |
| EGR2 | NM_000399 | early growth response 2 | 13.6 |
| EGR3 | NM_004430 | early growth response 3 | 22.8 |
| EGR4 | NM_001965 | early growth response 4 | 5.2 |
| ETV5 | NM_004454 | ets variant 5 | 3.2 |
| FOS | NM_005252 | FBJ murine osteosarcoma viral oncogene homolog | 3.5 |
| FOSB | NM_006732 | Homo sapiens FBJ murine osteosarcoma viral oncogene homolog B (FOSB) | 3.7 |
| FOSL1 | NM_005438 | FOS-like antigen 1 | 4.7 |
| FOSL2 | NM_005253 | FOS-like antigen 2 | 2.5 |
| HES1 | NM_005524 | hairy and enhancer of split 1, (Drosophila) | 3.4 |
| HOXB8 | NM_024016 | homeobox B8 | 14.1 |
| JUNB | NM_002229 | jun B proto-oncogene | 2.1 |
| KLF10 | NM_005655 | Kruppel-like factor 10 (KLF10), transcript variant 1 | 7.5 |
| KLF2 | NM_016270 | Kruppel-like factor 2 (lung) | 2.9 |
| MAFF | NM_012323 | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (MAFF), transcript variant 1 | 2.6 |
| MYC | NM_002467 | v-myc myelocytomatosis viral oncogene homolog (avian) | 4.1 |
| NAB2 | NM_005967 | NGFI-A binding protein 2 (EGR1 binding protein 2) | 2.2 |
| NOC2L | NM_015658 | nucleolar complex associated 2 homolog (S. cerevisiae) | 2.6 |
| PBX2 | NM_002586 | pre-B-cell leukemia homeobox 2 | 2.7 |
| POLR3E | AB040885 | mRNA for KIAA1452 protein, partial cds. | 4.0 |
| RYBP | NM_012234 | RING1 and YY1 binding protein | 2.3 |
| SF1 | NM_004630 | splicing factor 1 | 6.4 |
| SKIL | NM_005414 | SKI-like (SKIL) | 3.1 |
| SMAD7 | NM_005904 | SMAD family member 7 | 2.2 |
| ST18 | NM_014682 | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) | 2.0 |
| ZFP36 | NM_003407 | zinc finger protein 36, C3H type, homolog (mouse) | 2.3 |
| ZFP36L1 | NM_004928 | zinc finger protein 36, C3H type-like 1 | 2.6 |
| TRANSPORTERS | |||
| AP1S1 | NM_057089 | adaptor-related protein complex 1, sigma 1 subunit (AP1S1), transcript variant 2 | 2.3 |
| APOL6 | NM_030641 | apolipoprotein L, 6 | 3.9 |
| GGA1 | NM_001001560 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 3.1 |
| MCL1 | NM_021960 | myeloid cell leukemia sequence 1 (BCL2-related) | 2.3 |
| SLC2A14 | BC060766 | solute carrier family 2 (facilitated glucose transporter), member 14, mRNA (cDNA clone MGC:71510 IMAGE:5297510), complete cds. [BC060766] | 2.9 |
| SLC2A3 | NM_006931 | solute carrier family 2 (facilitated glucose transporter), member 3 | 2.5 |
| STX1A | NM_004603 | syntaxin 1A (brain) (STX1A) | 2.5 |
| TMC6 | NM_152453 | transmembrane and coiled-coil domains 5 (TMCO5) | 3.3 |
| PHOSPHATASES | |||
| DUSP4 | NM_001394 | dual specificity phosphatase 4 | 2.7 |
| DUSP5 | NM_004419 | dual specificity phosphatase 5 | 2.1 |
| DUSP6 | NM_001946 | dual specificity phosphatase 6 | 19.9 |
| EYA4 | NM_004100 | eyes absent homolog 4 (Drosophila) | 2.1 |
| OTHERS | |||
| ADM | NM_001124 | adrenomedullin | 2.4 |
| CASC5 | NM_170589 | cancer susceptibility candidate 5 (CASC5), transcript variant 1 | 3.3 |
| CCDC71 | NM_022903 | coiled-coil domain containing 71 | 3.1 |
| CCND1 | NM_053056 | cyclin D1 | 8.3 |
| CDKN1A | NM_000389 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 2.5 |
| CLN8 | NM_018941 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 2.2 |
| PSCD4 | NM_013385 | pleckstrin homology, Sec7 and coiled-coil domains 4 (PSCD4), | 3.4 |
| DDIT4 | NM_019058 | Homo sapiens DNA-damage-inducible transcript 4 (DDIT4), | 2.4 |
| FAM40B | NM_020704 | family with sequence similarity 40, member B (FAM40B) | 4.4 |
| FBXL17 | BC018548 | F-box and leucine-rich repeat protein 17, mRNA (cDNA clone IMAGE:4215262), partial cds. [BC018548] | 5.1 |
| FST | NM_013409 | follistatin | 2.2 |
| GNL3L | NM_019067 | guanine nucleotide binding protein-like 3 (nucleolar)-like | 2.3 |
| GOLGA1 | NM_002077 | golgin A1 | 3.7 |
| HNRNPA0 | NM_006805 | heterogeneous nuclear ribonucleoprotein A0 (HNRPA0) | 3.0 |
| IER2 | NM_004907 | immediate early response 2 | 2.5 |
| IER3 | NM_003897 | immediate early response 3 | 9.2 |
| LMNB1 | NM_005573 | lamin B1 | 3.0 |
| LRRC8B | NM_015350 | leucine rich repeat containing 8 family, member B (LRRC8B) | 2.0 |
| LUZP1 | NM_033631 | leucine zipper protein 1 (LUZP1) | 2.8 |
| MALAT1 | NR_002819 | metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) | 4.9 |
| MED18 | NM_017638 | mediator of RNA polymerase II transcription, subunit 18 homolog (S. cerevisiae) (MED18) | 15.0 |
| METTL7A | NM_014033 | methyltransferase like 7A | 2.6 |
| MYEOV | NM_138768 | myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas) | 3.7 |
| NUP188 | BC005407 | nucleoporin 188kDa, mRNA (cDNA clone IMAGE:3461492), partial cds. [BC005407] | 2.8 |
| PER2 | NM_022817 | period homolog 2 (Drosophila) | 2.5 |
| PHLDA1 | NM_007350 | pleckstrin homology-like domain, family A, member 1 | 9.7 |
| PHLDA2 | NM_003311 | pleckstrin homology-like domain, family A, member 2 | 2.3 |
| PMAIP1 | NM_021127 | phorbol-12-myristate-13-acetate-induced protein 1 | 3.6 |
| PRNP | NM_000311 | prion protein | 3.2 |
| RAPGEF5 | D87467 | mRNA for KIAA0277 gene, partial cds. [D87467] | 18.5 |
| RNF125 | NM_017831 | ring finger protein 125 | 5.1 |
| RPL23 | BC034378 | ribosomal protein L23, mRNA (cDNA clone MGC:34067 IMAGE:5186030), complete cds. [BC034378] | 2.3 |
| SERPINE1 | NM_000602 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 3.3 |
| SH2B3 | NM_005475 | SH2B adaptor protein 3 | 2.4 |
| SH2D2A | NM_003975 | SH2 domain protein 2A (SH2D2A) | 2.1 |
| SPRED1 | NM_152594 | sprouty-related, EVH1 domain containing 1 | 6.4 |
| SPRED2 | NM_181784 | sprouty-related, EVH1 domain containing 2 | 3.1 |
| SPRY2 | NM_005842 | sprouty homolog 2 (Drosophila) | 6.6 |
| TMEM49 | NM_030938 | transmembrane protein 49 | 7.3 |
| TMEPAI | NM_020182 | transmembrane, prostate androgen induced RNA (TMEPAI), transcript variant 1 | 4.2 |
| TNFRSF12A | NM_016639 | tumor necrosis factor receptor superfamily, member 12A | 4.8 |
| UBQLN1 | NM_013438 | ubiquilin 1 | 4.6 |
| ZC3H7B | NM_017590 | zinc finger CCCH-type containing 7B | 3.9 |
| ZCCHC2 | NM_017742 | zinc finger, CCHC domain containing 2 | 2.2 |
| ZNF295 | NM_020727 | zinc finger protein 295 (ZNF295) | 2.8 |
| VIL2 | NM_003379 | villin 2 (ezrin) (VIL2) | 2.3 |