Table 3.
Ingenuity biological function analyses of NGF regulated genes in HMC-1 (V560G c-Kit) cells (selected).
|
CATEGORY sub category or function annotation |
P-value | NGF induced molecules |
|---|---|---|
| 1. CELL DEATH | ||
| Apoptosis | 1.71E-15 | AATK, ADM, ATF3, CCND1, CDKN1A, CLCF1, CLN8, CXCR4, CYCS, DDIT4, DUSP4, DUSP6, EGR1, EGR2, EGR3, EGR4, EZR, FASLG, FOS, FOSB, FOSL1, FST, GDF15, HES1, IER3, IL1B, KLF2, KLF10, LIF, LMNB1, LTB, MCL1, MYC, NOC2L, NR4A1, NR4A2, NR4A3, PHLDA1, PHLDA2, PLK3, PMAIP1, PMEPA1, PRNP, RYBP, SERPINE1, SGK1, SKIL, SLC2A3, SMAD7, SPRY2, STX1A, TNFRSF12A, TRIB1, ZFP36 |
| Cell survival | 1.61E-04 | CCND1, CDKN1A, CLCF1, DUSP5, DUSP6, EGR3, FASLG, GDF15, HES1, IL1B, LIF, MCL1, MYC, NR4A1, PRNP, SERPINE1, SGK1, ZFP36 |
| 2. CELL GROWTH AND PROLIFERATION | ||
| Growth | 4.16E-12 | ADM, ARNTL2, ATF3, CCND1, CDKN1A, CXCR4, DUSP5, DUSP6, EGR1, EGR2, EZR, FASLG, FOS, FOSL1, FST, GDF15, GEM, GGA1, HNRNPA0, IER3, IL1B, JUNB, KLF2, KLF10, LIF, MAFF, MCL1, MYC, NR4A2, NR4A3, PHLDA1, PHLDA2, PMEPA1, PRNP, RRAD, SERPINE1, SF1, SGK1, SH2B3, SKIL, SMAD7, SPRY2, TMEM49, TNFRSF12A |
| Proliferation | 3.46E-10 | ADM, CCND1, CDKN1A, CLCF1, CTSZ, CXCR4, EGR1, EGR2, EGR3, FASLG, FOS, FOSB, FOSL1, FOSL2, FST, GDF15, HES1, HRH1, IER3, IL1B, JUNB, KLF2, KLF10, LIF, MYC, NAB2, NR4A1, NR4A3, PMAIP1, PRNP, SERPINE1, SF1, SH2B3, SH2D2A, SKIL, SMAD7, SPRED1, SPRY2, TNFRSF12A, TRIB1, ZFP36, ZFP36L1 |
| 3. CELL DEVELOPMENT | ||
| Development of blood cells | 1.24E-11 | ADM, CCND1, CDKN1A, CLCF1, CXCR4, DUSP5, EGR1, EGR2, EGR3, EZR, FASLG, FOS, FOSL1, HRH1, IER3, IL1B, JUNB, KLF2, KLF10, LFNG, LIF, LTB, MYC, NR4A1, PRNP, SH2B3, SH2D2A, SMAD7, SPRED2, TNFRSF12A, ZFP36 |
| Development of tumor cell lines | 1.20E-10 | ADM, ATF3, CCND1, CDKN1A, CXCR4, DUSP5, EGR1, EGR2, FOS, FOSL1, FST, GDF15, GEM, HES1, IER3, IL1B, KLF2, LIF, MCL1, MYC, NAB2, NR4A2, PMEPA1, PRNP, RRAD, SERPINE1, SMAD7, SPRY2, TMEM49 |
| Differentiation of cells | 5.57E-09 | ATF3, CCND1, CDKN1A, CLCF1, CXCR4, DUSP5, EGR1, EGR2, EGR3, FASLG, FOS, FOSL1, FOSL2, FST, HES1, HRH1, IL1B, JUNB, KLF10, LIF, MAFF, MCL1, MYC, NAB2, NR4A1, NR4A2, NR4A3, PRNP, SH2B3, SKIL, SMAD7, SPRED1, SPRED2, SPRY2, TNFRSF12A, ZFP36 |
| Haematopoesis | 2.82E-05 | ATF3, CCND1, CDKN1A, CLCF1, CXCR4, DUSP5, EGR1, EGR2, EGR3, FASLG, FOS, FOSL1, FOSL2, FST, HES1, HRH1, IL1B, JUNB, KLF10, LIF, MAFF, MCL1, MYC, NAB2, NR4A1, NR4A2, NR4A3, PRNP, SH2B3, SKIL, SMAD7, SPRED1, SPRED2, SPRY2, TNFRSF12A, ZFP36 |
| Maturation of cells | 1.73E-05 | CCND1, CDKN1A, EGR1, FASLG, FOS, HES1, IL1B, LFNG, LIF, MYC, NR4A2, PRNP |
| 4. CELL MORPHOLOGY | ||
| Morphology | 8.65E-10 | ADM, ATF3, CCND1, CDKN1A, EGR1, EZR, FOS, FOSL1, GDF15, GEM, JUNB, KLF2, LIF, MYC, PLK3, SERPINE1 |
| Cell size | 5.16E-04 | CCND1, CDKN1A, KLF2, MYC |
| 5. CELLULAR FUNCTION AND MAINTAINANCE | ||
| T cell development | 2.19E-09 | CCND1, CDKN1A, CXCR4, EGR1, EGR2, EGR3, EZR, FASLG, FOS, IER3, IL1B, JUNB, KLF2, KLF10, LFNG, LIF, LTB, MYC, NR4A1, PRNP, SH2D2A, SMAD7 |
| Cell death of T lymphocytes | 8.90E-09 | CDKN1A, CXCR4, EGR1, EGR3, EZR, FASLG, FOS, IER3, IL1B, KLF2, MYC, NR4A1, SH2D2A, SMAD7 |
| 6. GENE EXPRESSION | ||
| Transcription | 3.62E-08 | ATF3, CCND1, CDKN1A, CSRNP1, DUSP4, EGR1, EGR2, EGR4, ETV5, FASLG, FOS, FOSB, FOSL1, FOSL2, FST, HES1, IL1B, JUNB, KLF2, KLF10, LIF, MAFF, MYC, NAB2, NOC2L, NR4A1, NR4A2, NR4A3, PBX2, PER2, RYBP, SGK1, SH2B3, SH2D2A, SKIL, SMAD7, ST18, ZFP36 |
| Gene activation | 7.79E-06 | CCND1, EGR2, FOS, FOSB, FOSL1, FOSL2, KLF2, LIF, MYC, NR4A1, NR4A2 |
| Gene repression | 5.37E-05 | FOS, FOSB, HES1, KLF10, MYC, NR4A2 |