FIG. 3.

Incidence of blood–brain barrier (BBB) permeability breakdown in rats subjected to reduced cerebral perfusion pressure (CPP) from 70, 50, and 30 mm Hg by decreasing mean arterial pressure (MAP) or increasing intracranial pressure (ICP) as demonstrated by increased fluorescein isothiocyanate-labeled dextran fluorescence. Shown are readings in the red squares on the micrographs at baseline CPP (a) and at CPP of 30 mm Hg (b) with extravasation of fluorescein dye into the tissue. The graph illustrates the mean±standard error of the mean (SEM; n=10 rats/group) of fluorescein isothiocyanate fluorescence in absolute units (a.u.) at CPP of 70, 50, and 30 mm Hg by increasing ICP and decreasing MAP.