TABLE 1.

Animals and clinicopathological findings

Animal	Duration of infection (weeks)	Radiographic resultsa	Disease course	Granulomas
				Total no.e	No. of solid granulomas	No. of necrotic granulomas	Size (μm2)f
M7100	9b	+	Moderate disease	2	0	2	424,136-1,820,000
M15300	10c	+++	Advanced disease	233	56	177	16,836-5,486,090
M15000	16b	++	Moderate disease	13	12	1	20,185-996,507
M14600	17b	−	No diseased	0
M15100	17b	+	Moderate disease	7	6	1	33,606-1,020,000
M11301	32c	+++	Advanced disease	15	9	6	40,992-1,250,000
M11201	37c	+++	Advanced disease	24	12	12	28,620-2,327,970
M7200	41c	+++	Advanced disease	7	4	3	14,882-2,060,000
M15200	64b	−	Minimal disease	0

^aRadiographic results at necropsy. M14600 was the only macaque that did not have a positive radiographic result. However, viable M. tuberculosis bacilli were cultured from lung homogenates at necropsy. Scoring of − to +++ was based on the extent of involvement as described previously (11).

^bSacrificed at a scheduled time.

^cSacrificed due to extreme clinical symptoms.

^dOnly a few macroscopic granulomas were observed at necropsy.

^eNumber of granulomas examined in tissues.

^fSurface area in 14-μm tissue sections.