Table 3.
Demographic, Injury Severity, and Mortality Rate by the Three NOS3 Variants
| |
-786T>C |
|
894G>T |
|
27-bp VNTR |
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T/T | T/C | C/C | p Value | G/G | G/T | T/T | p Value | 4a/4a | 4a/4b | 4b/4b | p Value | |
| Demographic characteristics | ||||||||||||
| Number | 25 | 24 | 2 | 35 | 15 | 1 | 4 | 16 | 31 | |||
| Age | 38.2±2.9 | 31.1±2.3 | 44.0±23.0 | 0.128 | 35.5±2.4 | 33.9±3.5 | 41 | 0.717 | 38.0±5.7 | 34.9±3.3 | 34.8±2.7 | 0.911 |
| Race: African-American | 9 (36%) | 8 (33%) | 1 (50%) | 0.635 | 14 (40%) | 4 (27%) | 0 | 0.433 | 1 (25%) | 10 (63%) | 7 (23%) | 0.093 |
| Asian | 2 (8%) | 0 | 0 | 2 (6%) | 0 | 0 | 0 | 0 | 2 (6%) | |||
| Caucasian | 8 (32%) | 11 (46%) | 0 | 13 (37%) | 6 (40%) | 0 | 0 | 3 (19%) | 9 (29%) | |||
| Hispanic | 6 (24%) | 5 (21%) | 1 (50%) | 6 (17%) | 5 (33%) | 1 (100%) | 3 (75%) | 3 (19%) | 13 (42%) | |||
| Admission injury severity characteristics | ||||||||||||
| Motor GCS | 3.2±0.4 | 3.3±0.4 | 3.5±2.5 | 0.947 | 3.2±0.3 | 3.3±0.4 | 5 | 0.864 | 2.8±0.9 | 3.5±0.5 | 3.2±0.3 | 0.751 |
| Reactive pupils: Both | 13 (52%) | 14 (58%) | 1 (50%) | .883 | 19 (54%) | 8 (53%) | 1 (100%) | .902 | 2 (50%) | 9 (56%) | 15 (48%) | 0.948 |
| Reactive pupils: One | 5 (20%) | 3 (13%) | 0 | 5 (14%) | 3 (20%) | 0 | 1 (25%) | 3 (19%) | 5 (16%) | |||
| Reactive pupils: None | 7 (28%) | 7 (29%) | 1 (50%) | 11 (31%) | 4 (27%) | 0 | 1 (25%) | 4 (25%) | 11 (35%) | |||
| CT code: D1/D2 | 6 (24%) | 9 (38%) | 0 | 0.455 | 11 (31%) | 3 (20%) | 1 (100%) | 0.073 | 1 (24%) | 5 (31%) | 12 (39%) | 0.882 |
| CT code: D3/D4 | 6 (24%) | 6 (25%) | 0 | 5 (14%) | 7 (47%) | 0 | 1 (24%) | 2 (13%) | 6 (19%) | |||
| CT code: EM | 13 (52%) | 9 (38%) | 2 (100%) | 19 (54%) | 5 (33%) | 0 | 2 (50%) | 9 (56%) | 13 (42%) | |||
| SAH, yes | 20 (80%) | 19 (79%) | 1 (50%) | 0.607 | 27 (77%) | 12 (80%) | 1 (100%) | 0.859 | 3 (75%) | 13 (81%) | 24 (77%) | 0.941 |
| SAH, no | 5 (20%) | 5 (21%) | 1 (50%) | 8 (23%) | 3 (20%) | 0 | 1 (25%) | 3 (19%) | 7 (23%) | |||
| EDH, yes | 5 (20%) | 5 (21%) | 0 | 0.774 | 7 (20%) | 3 (20%) | 0 | 0.883 | 0 | 4 (25%) | 2 (6%) | 0.130 |
| EDH, no | 20 (80%) | 19 (79%) | 2 (100%) | 28 (80%) | 12 (80%) | 1 (100%) | 4 (100%) | 12 (75%) | 29 (94%) | |||
| Hypoxia, yes | 4 (16%) | 4 (17%) | 0 | 0.822 | 7 (20%) | 1 (7%) | 0 | 0.449 | 2 (50%) | 2 (13%) | 4 (13%) | 0.145 |
| Hypoxia, no | 21 (84%) | 20 (83%) | 2 (100%) | 28 (80%) | 14 (93%) | 1 (100%) | 2 (50%) | 14 (87%) | 27 (87%) | |||
| Hypotension, yes | 3 (12%) | 2 (8%) | 0 | 0.814 | 7 (20%) | 1 (7%) | 0 | 0.449 | 1 (25%) | 3 (19%) | 3 (10%) | 0.549 |
| Hypotension, no | 22 (88%) | 22 (92%) | 2 (100%) | 28 (80%) | 14 (93%) | 1 (100%) | 3 (75%) | 13 (81%) | 28 (90%) | |||
| Hemoglobin (g/dL) | 9.5±1.7 | 12.7±1.0 | 13.0±1.0 | 0.290 | 13.4±0.4 | 13.4±0.4 | 13.5 | 0.961 | 12.1±1.7 | 13.8±0.5 | 13.3±0.4 | 0.389 |
| Glucose (mmol/L) | 9.6±0.7 | 9.7±1.0 | 8.7±1.0 | 0.935 | 9.1±0.4 | 9.8±0.8 | 5.9 | 0.523 | 10.8±2.6 | 8.0±0.4 | 9.7±0.5 | 0.109 |
| Injury Severity Score | 31.4±1.7 | 32.0±1.8 | 37.5±12.5 | 0.658 | 30.9±1.4 | 34.7±2.5 | 20 | 0.163 | 36.7±4.6 | 31.6±1.9 | 31.5±1.7 | 0.539 |
| Predicted outcome | ||||||||||||
| IMPACT risk of death | 0.36±0.04 | 0.29±0.05 | 0.37±0.18 | 0.519 | 0.34±0.04 | 0.33±0.05 | 0.10 | 0.948 | 0.48±0.11 | 0.28±0.04 | 0.34±0.04 | 0.254 |
| IMPACT risk of poor outcome | 0.54±0.05 | 0.43±0.06 | 0.55±0.25 | 0.331 | 0.50±0.05 | 0.49±0.07 | 0.20 | 0.955 | 0.68±0.10 | 0.44±0.07 | 0.49±0.05 | 0.272 |
| Alive at 6 months, yes | 20 (80%) | 20 (83%) | 0 | 0.022 | 30 (86%) | 10 (67%) | 1 (100%) | 0.264 | 3 (75%) | 13 (81%) | 25 (81%) | 0.960 |
| Alive at 6 months, no | 5 (20%) | 4 (17%) | 2 (100%) | 5 (14%) | 5 (33%) | 0 | 1 (25%) | 3 (19%) | 6 (19%) | |||
GCS, Glasgow Coma Scale; CT, computed tomography; D1/D2, diffuse injury 1 and 2 by Marshall CT category; D3/D4, diffuse injury 3 and 4 by Marshall CT category; EM, evacuated mass lesion by Marshall CT category; SAH, subarachnoid hemorrhage; EDH, epidural hematoma; IMPACT risk of death and risk of poor outcome, predicted outcome by IMPACT indices; NOS, nitric oxide synthase.