Figure 2.

CGRP (200, 400, 800 ng/side) infused bilaterally into the lateral BNST increased acoustic startle response in a dose-dependent manner (data are expressed as percentage change compared with preinfusion startle levels for each animal). A, Time course of CGRP effects on startle. B, Mean (±SEM) percentage change from preinfusion baseline to the final 60 min of postinfusion testing. Repeated-measures ANOVA indicated a significant effect of dose, and planned comparisons revealed that both 400 and 800 ng produced significant increases compared with vehicle. *p < 0.05 versus vehicle.