. Author manuscript; available in PMC: 2011 May 6.

Published in final edited form as: J Cell Biochem. 2006 Dec 15;99(6):1463–1475. doi: 10.1002/jcb.21067

TABLE I.

DSB Disorders

Syndrome	Gene	Phenotype
AT	ATM	Immunodeficiency, neurodegeneration, cancer predisposition
ATLD	Mre11	Milder form of AT, no reported cancer phenotype
NBS	Nbs1	Immunodeficiency, developmental defects, cancer predisposition
Seckel syndrome	ATR	Developmental defects, no reported cancer phenotype
Fanconi anemia	BRCA2 (FANCD1)	Immunodeficiency, developmental defects, cancer predisposition
RS-SCID	Artemis	Immunodeficiency, no reported cancer phenotype
LIG4 syndrome	LIG4	Immunodeficiency, developmental defects, cancer predisposition