Table 1.

Classification of Drug Induced Cholestasis Syndromes

I. INTRAHEPATIC DRUG INDUCED CHOLESTASIS

a) Acute

i. Cholestasis without hepatitis (pure, simple, canalicular, or bland cholestasis)

ii. Cholestasis with hepatitis (hepatocanalicular hepatitis or mixed cholestatic hepatitis)

iii. Cholestasis with bile duct injury (ductular, cholangiolar, or cholangiolytic cholestasis)

b) Chronic (Cholangiopathies)

i Mild non-specific bile duct injury

ii. Vanishing bile duct syndrome (VBDS)

iii Primary Sclerosing cholangitis-like

ll, EXTRAHEPATIC DRUG INDUCED CHOLESTASIS

i. Cholelithiasis

ii.Primary Sclerosing cholangitis-like