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. Author manuscript; available in PMC: 2011 May 6.
Published in final edited form as: Surg Res Commun. 1987;1:325–331.

TABLE 1.

EFFECT OF FR 900506 IN VARIOUS DOSES UPON THE GRAFT SURVIVAL OF LEWIS RATS RECEIVING ACI HEART

Treatment Rat No. Graft Survival (Days) Median (Days) P-value @
Control 7 6, 6, 6, 6, 7, 7, 7 6 -
0.02 mg/kg I.M. daily for 14 days 6 7, 7, 8, 8, 9, 9 8 <0.05
0.04 mg/kg I.M. daily for 14 days 6 9, 10, 10, 11, 24, 34 10, 5 <0.01
0.08 mg/kg I.M. daily for 14 days 6 12, 14, 32, 36, 40, 10* 32 <0.01
0.16 mg/kg I.M. daily for 14 days 6 27, 30, 32, 33, 55, 14* 32 <0.01
0.32 mg/kg I.M daily for 14 days 6 27, 30, 37, 39, 39, 49 38 <0.01
0.64 mg/kg I.M. daily for 14 days 6 33, 34, 36, 42, 43, 84 39 <0.01
1.28 mg/kg I.M. daily for 14 days 6 56, 71, 80, 94, 96, >150 87 <0.01
@

Compared with control group

*

Died with living graft