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. 2010 Apr 21;66(Pt 5):604–615. doi: 10.1107/S090744491000644X

Figure 4.

Figure 4

Two examples of proteins crystallized by the surface-entropy reduction (SER) method. (a) The RGSL domain of the PDZRhoGEF nucleotide-exchange factor (PDB code 1htj; Longenecker, Lewis et al., 2001 ▶); the yellow spheres show the alanines introduced by mutagenesis, which mediate an isologous crystal contact across a crystallographic twofold axis. (b) The crystal structure of EpsI complexed with EpsJ (PDB code 2ret; Yanez et al., 2008 ▶); the EpsI protein (pale blue) contains two surface mutations, shown by yellow spheres, which mediate heterologous crystal contacts.