Table 2.
Univariate and multivariate analyses of failure after extirpative procedure.
| Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|
| Characteristics | RR | 95% CI | p | RR | 95% CI | p |
| Age at procedure (years) | ||||||
| <30 | 1.05 | (0.70–1.57) | 0.81 | 0.94 | (0.60–1.47) | 0.79 |
| 30–45 | 1.17 | (0.72–1.89) | 0.53 | 1.01 | (0.73–1.40) | 0.94 |
| >45 | 1.00 | – | – | 1.00 | – | – |
| Ethnicity | ||||||
| African American | 1.78 | (1.11–2.87) | 0.02 | 1.47 | (0.93–2.34) | 0.10 |
| Caucasian | 1.94 | (1.07–3.51) | 0.03 | 1.63 | (0.94–2.85) | 0.08 |
| Hispanic | 1.00 | – | – | 1.00 | – | – |
| Other | 1.73 | (0.97–3.08) | 0.06 | 1.50 | (0.79–2.82) | 0.21 |
| Current smoker | 0.75 | (0.54–1.05) | 0.09 | |||
| Intravenous drug use | 1.09 | (0.71–1.66) | 0.70 | |||
| Parity (multiparous vs. nulliparous) | 1.09 | (0.39–3.01) | 0.87 | |||
| Ever had an STI | 1.16 | (0.83–1.63) | 0.37 | |||
| Current hormone contraceptive use | 0.82 | (0.35–1.95) | 0.66 | |||
| Missed appointments | ||||||
| Rarely (0–3) | 1.00 | – | – | |||
| Frequently (3+) | 1.23 | (0.86–1.75) | 0.26 | |||
| Current HAART use | 0.98 | (0.71–1.35) | 0.89 | |||
| Time to first follow-up | ||||||
| ≤6 months | 1.00 | – | – | 1.00 | – | – |
| >6 months | 1.44 | (1.07–1.96) | 0.02 | 1.13 | (0.82–1.54) | 0.46 |
| Result of LEEP/cone specimen | ||||||
| <CIN 2 | 1.00 | – | – | |||
| ≥CIN 2 | 1.08 | (0.78–1.48) | 0.66 | |||
| Procedure type | ||||||
| LEEP | 1.39 | (0.94–2.05) | 0.10 | 1.76 | (1.17–2.64) | 0.007 |
| Conization | 1.00 | – | – | 1.00 | – | – |
| Margin status (endo- and ectocervical) | ||||||
| Both positive | 1.98 | (1.23–3.19) | 0.01 | 1.23 | (0.77–1.91) | 0.35 |
| Either positive | 1.73 | (1.11–2.69) | 0.02 | 0.99 | (0.66–1.48) | 0.97 |
| Both negative | 1.00 | – | – | 1.00 | – | – |
| CD4 count at time of procedure (±8 weeks) | ||||||
| ≤200 cells/µL | 3.55 | (1.44–8.74) | 0.006 | 2.93 | (1.06–8.11) | 0.04 |
| 201–500 cells/µL | 2.86 | (1.16–7.07) | 0.02 | 2.23 | (0.79–6.29) | 0.13 |
| >500 cells/µL | 1.00 | – | – | 1.00 | – | – |
| Viral load at time of procedure (±8 weeks) | ||||||
| Undetectable | 1.00 | – | – | |||
| Detectable –20,000 copies/mL | 1.12 | (0.76–1.65) | 0.56 | |||
| >20,000 copies/mL | 1.17 | (0.79–1.72) | 0.44 | |||
All significant p-values (p<0.05) were italicized.