Table 3.
Univariate and multivariate analyses of recurrence after extirpative procedure.
| Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|
| Characteristics | HR | 95% CI | p | HR | 95% CI | p |
| Age at procedure (years) | ||||||
| <30 | 1.39 | (0.46–4.18) | 0.56 | 0.28 | (0.10–1.29) | 0.07 |
| 30–45 | 1.33 | (0.52–3.37) | 0.55 | 1.84 | (0.36–1.98) | 0.77 |
| >45 | 1.00 | – | – | 1.00 | – | – |
| Ethnicity | ||||||
| Black | 0.63 | (0.23–1.71) | 0.34 | |||
| Caucasian | 0.70 | (0.14–3.62) | 0.66 | |||
| Hispanic | – | – | – | |||
| Other | 1.00 | (0.28–3.53) | 1.00 | |||
| Current smoker | 0.49 | (0.22–1.11) | 0.09 | |||
| Intravenous drug use | 0.49 | (0.10–2.29) | 0.34 | |||
| Parity (multiparous vs. nulliparous) | 1.04 | (0.09–11.70) | 0.97 | |||
| Ever had an STI | 1.74 | (0.80–3.77) | 0.16 | |||
| Current hormone contraceptive use | 2.74 | (0.41–18.30) | 0.28 | |||
| Missed appointments | ||||||
| Rarely (0–3) | 1.00 | – | – | |||
| Frequently (3+) | 1.49 | (0.78–2.86) | 0.21 | |||
| Current HAART use | 0.84 | (0.38–1.84) | 0.67 | |||
| Time to first follow-up | ||||||
| ≤6 months | 1.00 | – | – | |||
| >6 months | 0.81 | (0.36–1.81) | 0.61 | |||
| Procedure type | ||||||
| LEEP | 3.26 | (1.52–7.00) | 0.005 | 3.38 | (1.55–7.39) | 0.02 |
| Conization | 1.00 | – | – | 1.00 | – | – |
| Margin status (endo-and ectocervical) | ||||||
| Both positive | 3.85 | (1.22–12.27) | 0.03 | 6.12 | (1.90–19.73) | 0.03 |
| Either positive | 2.07 | (0.94–4.60) | 0.09 | 2.58 | (0.16–6.16) | 0.12 |
| Both negative | 1.00 | – | – | 1.00 | – | – |
| CD4 count at time of procedure (±8 weeks) | ||||||
| ≤200 cells/µL | 1.47 | (0.44–4.95) | 0.53 | |||
| 201–500 cells/µL | 0.74 | (0.30–1.86) | 0.52 | |||
| >500 cells/µL | 1.00 | – | – | |||
| Viral load at time of procedure (±8 weeks) | ||||||
| Undetectable | – | – | – | –– | – | |
| Detectable –20,000 copies/mL | 0.56 | (0.21–1.50) | 0.28 | 0.62 | (0.26–1.48) | 0.43 |
| >20,000 copies/mL | 1.89 | (0.79–4.52) | 0.18 | 6.32 | (2.22–17.94) | 0.01 |
All significant p-values (p<0.05) were italicized.