. Author manuscript; available in PMC: 2012 Apr 15.

Published in final edited form as: Bioorg Med Chem. 2011 Mar 12;19(8):2582–2588. doi: 10.1016/j.bmc.2011.03.017

Table 2.

Selectivity profile for compound 25 ^a,^b

Kinase	% inhibition at 25 μM	Kinase	% inhibition at 25 μM	Kinase	% inhibition at 25 μM
JNK1	79%^c	BRAF	2%	MAPK14 (p-38α)	11%
JNK2	72%^c	CAMK1	2%	NEK1	0%
JNK3	18%^c	CDK1	3%	PDK1 direct	0%
MAPK14 (p-38α, direct)	2%	CHEK1 (CHK1)	0%	PI3Kα	4%
MAPK3 (ERK1)	3%	CHUK (IIKα)	0%	PIM1	0%
MAPK1 (ERK2)	4%	FRAP1 (mTOR)	0%	PRKCA (PKCα)	0%
AKT1	5%	GSK3α	16%	ROCK1	0%
AMPK A1	0%	MAK2K1 (MEK1)	0%	SPHK1	1%
AURK A1	0%	MAPK3K9 (MLK1)	0%	MAP4K2 (GCK)	1%

From Invitrogen (Life Technologies) kinase profiling service;

Values are means of at least two independent experiments;

Z’-LYTE assay.