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. 2003 Dec;71(12):6978–6985. doi: 10.1128/IAI.71.12.6978-6985.2003

FIG. 4.

FIG. 4.

In vivo reconstitution of phagocytosis activity by injection of 0.25 μg of IL-5 and/or 0.25 μg of IFN-γ in the peritoneal cavity of the KO mice. Zymosan was used as a marker for the phagocytosis activity of the neutrophils. A reconstitution of the 5-KO mice with 0.25 μg of IL-5 and a reconstitution of the γ-KO mice with 0.25 μg of IFN-γ led to a significant increase in the level of phagocytosis activity of the neutrophils. Moreover, a reconstitution of the γ/5-KO mice with 0.25 μg of IL-5 or 0.25 μg of IFN-γ led to a partial increase in the level of phagocytosis activity of the neutrophils. Only the injection of 0.25 μg of IL-5 and 0.25 μg of IFN-γ restored the complete phagocytosis activity of the neutrophils from γ/5-KO mice. The results from one of two consistent experiments is shown. Five mice were used for each group (*, P < 0.05; **, P < 0.03 [Mann-Whitney U test]). n.s., not significant.