Localization
of lymphoid cells in lesions of resected lungs. CD4+
(A, B, and C) and CD8+ (E, F, and G) T cells are
seen in the granulomatous-fibrotic areas of the lung (arrows) but not
in the necrotic (nec) zone or at the cavity (cav) surface.
CD4− CD8− cytotoxic cells
(TIA-1+) are seen at the cavity surface but not in
the necrotic zone (D) and are less frequent in the
granulomatous area (*). These cells contain cytotoxic granules that
stain TIA-1+ (H, inset). Magnifications, ×4
(A, D, and E), ×40 (B, C, F, G, and H), and ×100 (H,
inset).