TABLE 2.

Characteristics of lesions and lung tissue

Patient no.	Specimen or sitea	Histopathologic examination		Bacteriology		Genotypic analysis of selected drug targetsb								mRNA expression of:
		Lesion	Airway	AFB	Culture	rpoB	katG	inhA	pncA	embB	rpsL	rrs	gyrA	IL-2	IL-12	IFN-γ	iNOS
1	Sputum			Numerous	M. tuberculosis	WT	WT	WT	WT	WT	WT	NDc	WT
	LUL	Cavity wall (caseous necrosis)	Open	Numerous	M. tuberculosis	WT	WT	WT	WT	WT	K43R	ND	WT	120	190	5,400	ND
	LLL	Cavity wall (caseous necrosis)	Open	Numerous	ND									100	220	6,300	ND
	LLL	Granuloma (fibrocaseous)	Closed	Scanty	M. tuberculosis	WT	WT	WT	WT	WT	WT	ND	WT	85	415	5,000	ND
	LN	Granuloma (nonnecrotic)	Closed	None	ND									80	340	8,700	ND
2	Sputum			Numerous	M. tuberculosis	S531L	WT	C15T	WT	M306V	K88R	ND	WT
	RUL	Cavity wall (caseous necrosis)	Open	Moderate	M. tuberculosis	S531L	WT	C15T	WT	M306V	K88R	ND	D89N	107	244	3,149	46
	RLL	Cavity wall (caseous necrosis)	Open	Numerous	M. tuberculosis	S531L	WT	C15T	WT	M306V	K88R	ND	D94G	89	345	1,630	621
	RLL	Cavity wall (caseous necrosis)	Open	Scanty	M. tuberculosis	S531L	WT	C15T	WT	M306V	K88R	ND	D89N	28	136	1,465	21
	RML	Small nodule (caseous)	Closed	Scanty	M. tuberculosis	S531L	WT	C15T	WT	M306V	K88R	ND	WT	32	240	1,196	90
	RLL	Infarction (coagulative necrosis)	Closed	Scanty	M. tuberculosis	S531L	WT	C15T	WT	M306V	K88R	ND	WT	13	89	7,243	135
3	Sputum			Numerous	M. tuberculosis	S531L	S315T	WT	173 (T del)	M306V	K43R	WT	D94G
	LUL	Cavity wall (caseous necrosis)	Open	Moderate	M. tuberculosis	S531L	S315T	WT	173 (T del)	M306V	K43R	WT	D94G	80	199	7,536	207
	LLL	Cavity wall (caseous necrosis)	Open	Scanty	M. tuberculosis	S531L	S315T	WT	173 (T del)	M306V	K43R	WT	D94G	92	290	715	119
	LLL	Fibrotic nodule (liquefaction)	Open	Moderate	M. tuberculosis	S531L	S315T	WT	173 (T del)	M306V	K43R	G1484T	D94G	80	388	1,142	129
	LUL	Granuloma (caseous necrosis)	Closed	Moderate	M. tuberculosis	S531L	S315T	WT	173 (T del)	M306V	K43R	WT	D94G	175	421	1,861	38
	LLL	Miliary nodules (caseous)	Closed	Scanty	M. tuberculosis	S531L	S315T	WT	173 (T del)	M306V	K43R	WT	D94G	64	78	202	181
	LLL	Normal lung tissue		Scanty	M. tuberculosis	S531L	WT	WT	173 (T del)	WT	K43R	WT	ND	64	138	605	274
4	Sputum			None	Negative
	LUL	Granuloma (nonnecrotic)	Closed	None	Negative									101	197	857	96
	LUL	Granuloma (noncaseous)	Closed	Scanty	Negative									313	289	1,201	103
	LLL	Normal lung tissue		None	Negative									78	107	362	373
5	Sputum			None	Negative
	LUL	Cavity wall (no necrosis)	Open	None	Negative									168	409	2,407	102
	LLL	Granuloma (fibrotic)	Closed	None	Negative									76	325	2,066	14
6	Sputum			None	Negative
	LUL	Cavity wall (no necrosis)	Open	None	Negative									87	234	1,666	145
	LUL	Granuloma (caseous)	Closed	None	Negative									159	385	2,541	115
	LLL	Miliary nodules (caseous)	Closed	Scanty	Negative									90	152	1,321	270

^aLUL and RUL, Left and right upper lobe; LN, lymph node.

^bWT, wild type; boldface indicates changes in drug resistance compared to that in other lung lesions.

^cND, not done.