Impaired bacterial clearance in LBP−/− animals: numbers of CFU in PLF, liver, and blood 4 and 16 h after i.p. infection with E. coli of wild-type (wt) and LBP−/− mice. The bars indicate means and the error bars indicate standard errors of the means for eight or nine mice per strain at each time. The results are representative of the results of two independent experiments. A plus sign, an asterisk, and a number sign indicate that the P values are <0.0001, <0.0005, and <0.01, respectively, for a comparison with the data for wild-type mice.