Table 3.
HNF4A SNP-cluster associations with 2-h OGTT insulin in FUSION data
| Cluster No. | SNP | Position† | MAF | RO2‡ | RN2⁁ | (1 – RO2)/(1 – Rn2) ratio | p value§ |
|---|---|---|---|---|---|---|---|
| 1 | rs6073425 | 42447340 | 0.325 | 0.432 | 0.013 | 0.575 | 1.0 |
| rs2425637 | 42457463 | 0.496 | 0.730 | 0.105 | 0.302 | ||
| rs2425638 | 42460043 | 0.186 | 0.558 | 0.012 | 0.446 | ||
| rs2425640 | 42461451 | 0.369 | 0.796 | 0.056 | 0.216 | ||
| 2 | rs6031552 | 42412208 | 0.255 | 0.772 | 0.005 | 0.229 | 0.522 |
| rsll508795 | 42416627 | 0.115 | 0.506 | 0.078 | 0.536 | ||
| rs6031558 | 42433057 | 0.335 | 0.673 | 0.079 | 0.356 | ||
| rs6073418 | 42434004 | 0.287 | 0.337 | 0.130 | 0.762 | ||
| 3 | rs6031544 | 42415761 | 0.296 | 0.766 | 0.189 | 0.289 | 0.033 |
| rs2144908 | 42419131 | 0.175 | 0.737 | 0.019 | 0.268 | ||
| rs4812831 | 42451674 | 0.120 | 0.501 | 0.060 | 0.531 |
Based on HapMap data release 23a (phase II), NCBI build 36, dbSNP build 126.
Squared correlation coefficient between a given SNP and its own cluster.
The next highest squared correlation coefficient between a given SNP and any other cluster.
p value from 1 d.f. Wald χ2 for association with outcome, corrected for multiple testing with Bonferroni for number of clusters (n = 3).