Table 2.
Comparison of the Frequencies of the Risk alleles (Single Nucleotide Polymorphisms) in Prostate Cancer Cases with a “Normal” PSA and DRE and Healthy Volunteer Controls
| SNP | Chrom. Location |
Allele | Percent of | P Value | OR (95% CI) |
Best-Fit Genetic Model |
|
|---|---|---|---|---|---|---|---|
| Cases | Controls | ||||||
| rs721048 | 2p15 | A | 18.5 | 16.7 | 0.40 | 1.1 (0.8-1.5) | Recessive |
| rs10934853 | 3q21 | A | 31.8 | 27.1 | 0.07 | 1.3 (.10-1.6) | Dominant |
| rs2736098 | 5p15 | A | 31.8 | 26.0 | 0.029 | 1.3 (1.0-1.7) | Recessive |
| rs401681 | 5p15 | C | 57.1 | 54.0 | 0.27 | 1.1 (0.9-1.4) | Dominant |
| rs16901979 | 8q24 | A | 5.9 | 4.0 | 0.13 | 1.5 (0.9-2.5) | Dominant |
| rs16902094 | 8q24 | G | 15.3 | 13.8 | 0.46 | 1.1 (0.8-1.5) | Dominant |
| rs445114 | 8q24 | T | 63.6 | 63.3 | 0.95 | 1.0 (0.8-1.3) | Dominant |
| rs6983267 | 8q24 | G | 59.4 | 50.5 | 0.002 | 1.4 (1.1-1.8) | Dominant |
| rs1447295 | 8q24 | A | 14.3 | 8.6 | 0.002 | 1.8 (1.3-2.5) | Dominant |
| rs10993994 | 10q11 | T | 48.8 | 39.3 | 0.0009 | 1.5 (1.2-1.8) | Recessive |
| rs11228565 | 11q13 | A | 25.6 | 19.4 | 0.009 | 1.4 (1.1-1.9) | Dominant |
| rs10896450 | 11q13 | G | 57.6 | 49.5 | 0.005 | 1.4 (1.1-1.7) | Dominant |
| rs11649743 | 17q12 | G | 83.7 | 82.5 | 0.60 | 1.1 (0.8-1.5) | Recessive |
| rs4430796 | 17q12 | A | 54.7 | 51.6 | 0.28 | 1.1 (0.9-1.4) | Dominant |
| rs1859962 | 17q24 | G | 53.2 | 49.0 | 0.15 | 1.2 (0.9-1.5) | Recessive |
| rs8102476 | 19q13 | C | 60.6 | 57.8 | 0.32 | 1.1 (0.9-1.4) | Dominant |
| rs5945572 | Xp11 | A | 42.4 | 37.3 | 0.21 | 1.2 (0.9-1.7) | Dominant |