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Cumulative risk model including all 17 risk alleles and a positive family history*
| Carrier of Variants # |
Case N=195 N= (%) |
Control N=348 N= (%) | OR (95%C.I.) |
p-value |
|---|---|---|---|---|
| 0-5 | 11 (5.6) | 35 (10.1) | -- | |
| 6 | 9 (4.6) | 59 (17.0) | 0.5 (0.2-1.3) | 0.15 |
| 7 | 33 (16.9) | 66 (19.0) | 1.6 (0.7-3.5) | 0.25 |
| 8 | 36 (18.5) | 89 (25.6) | 1.3 (0.6-2.8) | 0.53 |
| 9 | 30 (15.4) | 56 (16.1) | 1.7 (0.8-3.8) | 0.20 |
| 10 | 37 (19.0) | 32 (9.2) | 3.7 (1.6-8.4) | 0.002 |
| >10 | 39 (20.0) | 11 (3.2) | 11.2 (4.3-29.2) | <0.0001 |
P-trend<0.001
