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. 2011 Mar 24;286(19):16606–16614. doi: 10.1074/jbc.M111.227611

FIGURE 1.

FIGURE 1.

miR-205 expression is down-regulated in melanoma and is inversely correlated with expression of E2F1 and E2F5. A, miRNA quantitative RT-PCR analysis of miR-205 expression level in a cohort of nevus and melanoma tissues. B, miR-205 expression in a panel of human melanoma cells and normal melanocytes (Mela). C, the miR-205 seed sequence is complementary to the 3′-UTR of E2F1 and E2F5 and is conserved in six different species. D and E, E2F1 and E2F5 expression at the mRNA and protein levels in different human melanoma cell lines and normal melanocytes. *, p < 0.05.