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A mechanistic model for the role of VGSC activity in VEGF HUVEC signaling. Heavy lines show direct interactions. Dashed lines show indirect interactions. Voltage-gated sodium channel (VGSC) activity is proposed to influence the [Ca2+]i close to the plasma membrane by modifying the membrane potential and subsequently reverse-mode NCX exchange (Ca2+ in, Na+ out). DAG, diacylglycerol; PIP2, phosphatidylinositol 4,5-bisphosphate.
