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. 2011 Mar 24;286(19):16914–16928. doi: 10.1074/jbc.M111.218735

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — PKA activators increase Cx50 and Cx43-mediated intercellular communications. A, lens primary cultures were treated or not with 8-Br-cAMP (1 mm) or forskolin (10 μm) and/or PKI (0.4 μm) for 2 h before scrape loading dye transfer assay. Both forskolin and 8-Br-cAMP dramatically increased Cx50/Cx43 gap junction coupling in lens primary cultures (n = 6). B, CEF cells expressing exogenous Cx50, Cx43, or both Cx50 and Cx43 were treated or not with 8-Br-cAMP (1 mm) and/or PKI (0.4 μm) for 2 h before scrape loading dye transfer assay. 8-Br-cAMP greatly increased Cx50, Cx43, and Cx50/Cx43-mediated intercellular communications (n = 6).