TABLE 1.
Mendelian percentage of mutants using various Cre lines
Jarid2F/F female mice were mated with different Jarid2F/+; Cre/+ male mice to generate endothelial, epicardial, myocardial, and neural crest-specific deletions of Jarid2F/F; Cre/+. The expected Mendelian ratio of Jarid2F/F; Cre/+ mice is 25% according to our breeding scheme. Only mice with an endothelial specific deletion of Jarid2 showed a significant reduction in the expected Mendelian ratio.
| Cre mouse | Number of pups examined | Percentage of mutants |
|---|---|---|
| Endothelial | ||
| Tie2 | 1006 | 6.9 |
| Epicardial | ||
| WT1 | 34 | 26 |
| Myocardial | ||
| αMHC | 66 | 21.2 |
| Nkx2.5 | 48 | 29.8 |
| Neural crest | ||
| Wnt1 | 65 | 23.1 |