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Cardiac phenotypic defects observed in Jarid2en mice
Jarid2en mice at various stages were examined by H&E staining on transverse sections. Jarid2en mice exhibited cardiac defects including VSD, noncompaction of the ventricular compact layer and hypertrabeculation, which recapitulated defects observed in Jarid2 KO mice.
| Genotype | Number analyzed | VSD | Noncompaction | Hypertrabeculation |
|---|---|---|---|---|
| Wild type | ||||
| E9.5–E12.5 | 7 | N/A | N/A | 0 |
| E13.5–E15.5 | 9 | 0 | 0 | 0 |
| Mutant | ||||
| E9.5–E12.5 | 11 | N/A | N/A | 10 |
| E13.5–E15.5 | 11 | 7 | 8 | 9 |
