FIGURE 10.

Rescuing the impaired intracellular trafficking of apoE4 with a structure corrector abolishes the apoE4 detrimental effect on neurite outgrowth. A–C, representative images of Neuro-2a cells expressing apoE3 (A), apoE4 (B), or apoE4 treated with PH002 (100 nm for 3 days) (C) in differentiation medium for 3 days are shown. D, quantification of neurite outgrowth in different Neuro-2a cells is shown. n = 4–6 per genotype and treatment. Values are the mean ± S.D. *, p < 0.01 (two-tailed t test).