. 2011 Mar 20;286(19):17227–17238. doi: 10.1074/jbc.M111.220483

TABLE 1.

Plasma cholesterol levels, lecithin:cholesterol acyltransferase (LCAT) activity, hematocrit, and spleen weight of mice fed a chow diet

Values were determined in overnight fasted age-matched mice fed a chow diet. Data represent mean ± S.D. Spleen mass was expressed per g of body weight. Lecithin:cholesterol acyltransferase activity is expressed as nanomol of CE transferred/h/ml.

Genotype	Gender	TC	FC:TC	LCAT activity	Hematocrit	Spleen
		mg/dl	%		%	mg/g
WT	F	73 ± 9	29 ± 2		47.4 ± 1.4	3.7 ± 0.3
	M	94 ± 3	25 ± 1	257 ± 49	48.4 ± 1.1	3.1 ± 0.5
WT/CETP	F	68 ± 13	28 ± 2		47.0 ± 2.9	4.2 ± 0.6
	M	83 ± 6	25 ± 1	224 ± 5	47.9 ± 0.9	3.0 ± 0.7
HypomSR-BI	F	130 ± 12^a	30 ± 1		47.6 ± 1.7	3.7 ± 0.3
	M	156 ± 10^a	31 ± 1^b	177 ± 51	46.9 ± 2.1	3.1 ± 0.8
HypomSR-BI/CETP	F	100 ± 15^a,c	31 ± 2		49.0 ± 2.6	3.9 ± 0.6
	M	111 ± 14^c	33 ± 2^a	233 ± 76	47.5 ± 2.2	3.1 ± 0.4
HypomSR-BI KO^liver	F	176 ± 13^a	49 ± 5^a		45.5 ± 1.9	5.9 ± 0.7^a
	M	182 ± 10^a	51 ± 3^a	112 ± 30^a	44.7 ± 2.2^b	5.4 ± 1.5^a
HypomSR-BI KO^liver/CETP	F	110 ± 9^a,c	49 ± 5^a		46.8 ± 1.6	4.7 ± 0.4^b,d
	M	117 ± 24^b,c	49 ± 4^a	230 ± 59^d	45.1 ± 2.1^b	3.8 ± 0.6^c
SR-BI^−/−	F	147 ± 6^a	51 ± 3^a		43.1 ± 1.6^b	6.6 ± 0.6^a
	M	137 ± 14^a	52 ± 6^a	106 ± 50^b	42.3 ± 1.9^a	5.9 ± 1.6^a
SR-BI^−/−/CETP	F	107 ± 9^a,c	47 ± 3^a		43.5 ± 1.9^b	6.2 ± 0.7^a
	M	94 ± 10^c	48 ± 1^a	265 ± 72^d	42.1 ± 1.6^a	4.5 ± 0.8^b,d

^a p < 0.001, statistically different from values for control mice.

^b p < 0.05, statistically different from values for control mice.

^c p < 0.001, statistically different from values for corresponding non-CETP transgenic mice.

^d p < 0.05, statistically different from values for corresponding non-CETP transgenic mice.