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. 2011 Mar 20;286(19):17227–17238. doi: 10.1074/jbc.M111.220483

TABLE 2.

Plasma lipid levels, hematocrit, and spleen weight of mice fed an atherogenic diet

Values were determined in overnight fasted female mice fed a 1.25% cholesterol diet for 20 weeks. Data represent mean ± S.D. Spleen mass was expressed per g of body weight.

Genotype TC FC:TC Hematocrit Spleen
mg/dl % mg/g
WT 85 ± 17 26 ± 6 44.3 ± 3.2 4.3 ± 1.3
WT/CETP 101 ± 23 24 ± 6 44.8 ± 1.7 4.6 ± 1.1
HypomSR-BI 180 ± 20a 27 ± 2 45.8 ± 2.9 3.8 ± 1.0
HypomSR-BI/CETP 158 ± 15a 27 ± 2 42.9 ± 3.8 4.6 ± 0.9
HypomSR-BI KOliver 331 ± 56a 62 ± 3a 35.9 ± 6.2a 22.0 ± 5.9a
HypomSR-BI KOliver/CETP 227 ± 48a,b 61 ± 6a 34.4 ± 3.9a 21.3 ± 7.6a
SR-BI−/− 311 ± 43a 62 ± 3a 34.3 ± 3.9a 25.8 ± 6.7a
SR-BI−/−/CETP 249 ± 28a,c 62 ± 3a 35.0 ± 4.1a 22.2 ± 5.0a

a p < 0.001, statistically different from values for control mice.

b p < 0.001, statistically different from values for corresponding non-CETP transgenic mice.

c p < 0.05, statistically different from values for corresponding non-CETP transgenic mice.