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Crystal structure of AIP-4·AP4-24H11. A, structure of AP4-24H11 Fab with AIP-4 inserted between the heavy chain (blue) and light chain (red) in the combining site. B, electrostatic surface of the 24H11 binding site (+3.0 kV (blue) to −3.0 kV (red)). The hydrophobic residues AIP-4 Phe6, Ile7, and Met8 are buried in a hydrophobic pocket. The negative potential beneath the ring arises from GluH95. A sodium ion is modeled as a purple sphere.
