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. Author manuscript; available in PMC: 2011 May 6.
Published in final edited form as: Nature. 2010 Sep 2;467(7311):112–116. doi: 10.1038/nature09355

Figure 3. RPA promotes 5'→3' degradation by Dna2 and inhibits 3'→5' degradation.

Figure 3

a, Duplex DNA substrates containing either a 5'- or 3'-ssDNA flap (red asterisk indicates the 32P-label) incubated with Dna2 (15 nM) and indicated RPA. b, Illustration summarizing results from panel a and Supplementary Figs. 4 and 5 showing modulation of ssDNA nuclease activities of Dna2.