Table 2. Protective genes.
| Microarray Results | qRT-PCR Validationa | |||
| Gene ID | Official gene name | Controlb | Emphysemab | End-stagec |
| D84105 | Membrane cofactor protein (CD46) | 12.0±1.0 | 9.0±0.5* d | 4.0±1* |
| NM_001228 | Caspase 8, apoptosis-related cysteine protease (Casp8) | 138.0±45.0 | 27.0±5‡ | 34.0±10* |
| U12767 | Nuclear receptor subfamily 4, group A, member 3 (NR4A3) | 23.0±9.0 | 27.0±15.0‡ | 4.0±1† |
| NM_001419 | Embryonic lethal, abnormal vision, Drosophila Antigen like 1 (Hu antigen R) | |||
| AF074480 | Cytidine monophosphate-N-acetylneuraminic acid hydroxylase(CMP-N-Acetylneuraminate monooxygenase) (CMAH) | |||
| NM_005911 | Methionine adenosyltransferase II, alpha (MATII) | |||
| BE870509 | Hepatocyte growth factor receptor (HGFR) | |||
| AA918442 | Insulin-degrading enzyme (IDE) | |||
| NM_006540 | Nuclear receptor coactivator 2 (NRCO2) | |||
| NM_003619 | Protease, serine, 12 (neurotrypsin, motopsin) (PRSS12) | |||
| M97935 | Signal transducer and activator of transcription 1, 91 kDa (STAT1) | 23.0±9.0 | 12.0±1.0 | 3.5±1.6 † |
| L38019 | Inositol 1,4,5-triphosphate receptor, type 1 (IP3R1) | |||
| NM_021140 | Ubiquitously transcribed tetratricopeptide repeat gene, X chrom.(UTX) | 1.3±0.4 | 2.0±1.2 | 0.6±0.3 § |
| AF074000 | Lectin, galactoside-binding, soluble, 8 (galectin 8) | |||
| NM_005734 | Homeodomain interacting protein kinase 3 (HIPK3) | |||
| NM_024530 | FOS-like antigen 2 (FOSL2) | |||
| AI638420 | Chloride intracellular channel 4 (CLIC4) | |||
| BE963370 | BCL2-associated transcription factor 1 (BCLAF1) | |||
a
mRNA expression tested in the same participants by microarray and quantitative RT-PCR which had either b lung resection for treatment of small peripheral cancer (n = 5); or c lung volume reduction surgery for emphysema (non-cancer, n = 4).
d
Values are expressed as average ± SD, P values are relative to control, calculated using two tailed T students test.
*
, p<0.0001;
†
, p<0.001;
‡
, p<0.01;
§
, p<0.05.