Table 4.

Odds ratios and 95% confidence intervals by inflammatory profile

Cytokine vs. Modulator	Low/Low	Low/High	High/Low	High/High
IL-1β vs. IL-1Ra
# cases/# controls	72/139	39/85	42/71	77/137
OR (95% CI)	1.0 (ref)	0.91 (0.57, 1.47)	1.15 (0.71, 1.85)	1.09 (0.73, 1.64)
p-value		0.71	0.57	0.67
IL-1β vs. sIL-1Rll
# cases/# controls	46/105	65/119	70/109	49/99
OR (95% CI)	1.0 (ref)	1.20 (0.76, 1.92)	1.43 (0.90, 2.27)	1.11 (0.68, 1.81)
p-value		0.43	0.13	0.69
IL-2 vs. sIL-2Ra
# cases/# controls	48/118	59/107	63/99	60/108
OR (95% CI)	1.0 (ref)	1.36 (0.85, 2.19)	1.56 (0.98, 2.47)	1.36 (0.85, 2.16)
p-value		0.20	0.06	0.20
IL-4 vs. sIL-4R
# cases/# controls	61/121	44/103	53/95	72/113
OR (95% CI)	1.0 (ref)	0.85 (0.53, 1.36)	1.11 (0.70, 1.76)	1.28 (0.84, 1.97)
p-value		0.50	0.65	0.25
IL-6 vs. sIL-6R
# cases/# controls	52/116	51/110	68/94	59/112
OR (95% CI)	1.0 (ref)	1.05 (0.66, 1.68)	1.65 (1.05, 2.61)	1.19 (0.76, 1.89)
p-value		0.84	0.03	0.45
IL-12p70 vs. IL-12p40
# cases/# controls	49/129	54/100	58/96	69/107
OR (95% CI)	1.0 (ref)	1.46 (0.92, 2.34)	1.62 (1.01, 2.58)	1.74 (1.11, 2.74)
p-value		0.11	0.04	0.02
TNFα vs. sTNF-R1
# cases/# controls	48/137	67/83	62/85	63/127
OR (95% CI)	1.0 (ref)	2.12 (1.30, 3.45)	2.13 (1.33, 3.41)	1.51 (0.95, 2.41)
p-value		0.002	0.002	0.08
TNFα vs. sTNF-R2
# cases/# controls	62/129	43/91	53/86	72/126
OR (95% CI)	1.0 (ref)	0.98 (0.61, 1.58)	1.28 (0.81, 2.03)	1.18 (0.76, 1.82)
p-value		0.94	0.29	0.46

Note: Each marker was classified as high or low based on the median value and then four groups were created for each pair. Models are unconditional logistic regression models, adjusted for the matching factors (age, cohort, menopausal status)