Table 3.
Genotype distribution and association with risk of pancreatic cancer
| Genotype | All study subjects | Non-Hispanic Whites | ||||||
|---|---|---|---|---|---|---|---|---|
| Case/Control n/n |
AOR (95% CI)a | AOR (95% CI)b | P valueb | Case/Control n/n |
AOR (95% CI)a | AOR (95% CI)b | P valueb | |
| PPARG Ex4−49C>G | ||||||||
| CC | 826/871 | 1.00 | 1.00 | 708/773 | 1.00 | 1.00 | ||
| CG | 216/236 | 1.00 (0.81–1.25) | 1.05 (0.82–1.35) | 0.68 | 196/212 | 1.05 (0.84–1.32) | 1.09 (0.84–1.41) | 0.53 |
| GG | 10/23 | 0.45 (0.21–0.99) | 0.21 (0.07–0.62) | 0.004** | 9/18 | 0.53 (0.23–1.21) | 0.30 (0.10–0.89) | 0.029 |
| PRKAA2 Ex9+2011A>C | ||||||||
| AA | 299/334 | 1.00 | 260/300 | 1.00 | 1.00 | |||
| AC | 539/555 | 1.10 (0.89–1.35) | 1.29 (1.01–1.63) | 0.038 | 470/495 | 1.06 (0.86–1.32) | 1.22 (0.95–1.57) | 0.11 |
| CC | 218/253 | 1.05 (0.82–1.35) | 1.19 (0.89–1.59) | 0.25 | 187/219 | 1.04 (0.80–1.36) | 1.17 (0.86–1.59) | 0.31 |
| PRKAB2 Ex7−247T>G | ||||||||
| TT | 478/491 | 1.00 | 1.00 | 408/438 | 1.00 | 1.00 | ||
| GT | 476/494 | 1.02 (0.85–1.23) | 1.09 (0.88–1.35) | 0.42 | 425/437 | 1.05 (0.86–1.28) | 1.10 (0.88–1.37) | 0.41 |
| GG | 101/138 | 0.75 (0.56–1.02) | 0.79 (0.56–1.12) | 0.19 | 84/127 | 0.72 (0.53–1.00) | 0.78 (0.54–1.12) | 0.18 |
| PRKAB1 −309C>A | ||||||||
| CC | 507/530 | 1.00 | 430/471 | 1.00 | 1.00 | |||
| AC | 458/495 | 1.00 (0.83–1.20) | 1.07 (0.86–1.32) | 0.54 | 411/438 | 1.04 (0.86–1.27) | 1.10 (0.88–1.37) | 0.42 |
| AA | 98/122 | 0.81 (0.59–1.11) | 0.82 (0.57–1.17) | 0.28 | 81/111 | 0.81 (0.58–1.12) | 0.84 (0.57–1.22) | 0.35 |
| PRKAB2 Ex8+1306G>A | ||||||||
| GG | 395/405 | 1.00 | 1.00 | 369/379 | 1.00 | 1.00 | ||
| AG | 499/531 | 0.92 (0.76–1.12) | 0.96 (0.77–1.20) | 0.74 | 434/462 | 0.94 (0.76–1.15) | 0.99 (0.79–1.25) | 0.95 |
| AA | 154/192 | 0.75 (0.57–0.99) | 0.75 (0.55–1.03) | 0.08 | 106/161 | 0.64 (0.47–0.86) | 0.69 (0.49–0.97) | 0.035 |
| NR5A2 −91147C>T | ||||||||
| CC | 401/401 | 1.00 | 339/350 | 1.00 | 1.00 | |||
| CT | 517/534 | 0.99 (0.81–1.20) | 0.91 (0.72–1.14) | 0.39 | 464/488 | 0.98 (0.80–1.20) | 0.92 (0.73–1.16) | 0.48 |
| TT | 137/198 | 0.65 (0.49–0.86) | 0.57 (0.42–0.78) | <0.001** | 111/169 | 0.62 (0.46–0.84) | 0.56 (0.40–0.78) | 0.001** |
| NR5A2 IVS2+1901C>T | ||||||||
| CC | 552/541 | 1.00 | 1.00 | 482/490 | 1.00 | 1.00 | ||
| CT | 410/478 | 0.83 (0.69–1.00) | 0.77 (0.62–0.96) | 0.02 | 364/430 | 0.84 (0.69–1.02) | 0.80 (0.64–1.00) | 0.05 |
| TT | 79/114 | 0.65 (0.46–0.91) | 0.61 (0.42–0.89) | 0.01 | 58/85 | 0.66 (0.46–0.97) | 0.61 (0.41–0.92) | 0.018 |
| NR5A2 IVS1−1354A>G | ||||||||
| AA | 670/652 | 1.00 | 1.00 | 592/596 | 1.00 | 1.00 | ||
| AG | 330/409 | 0.76 (0.63–0.92) | 0.71 (0.57–0.88) | 0.002** | 286/362 | 0.75 (0.62–0.92) | 0.73 (0.58–0.91) | 0.006 |
| GG | 55/75 | 0.72 (0.48–1.08) | 0.79 (0.50–1.24) | 0.31 | 38/52 | 0.75 (0.48–1.19) | 0.80 (0.48–1.32) | 0.37 |
| ADIPOQ Ex3+117T>C | ||||||||
| TT | 988/1051 | 1.00 | 1.00 | 856/930 | 1.00 | 1.00 | ||
| CT | 66/86 | 0.82 (0.58–1.16) | 0.67 (0.45–0.99) | 0.047 | 59/79 | 0.79 (0.55–1.13) | 0.66 (0.43–1.00) | 0.048 |
| CC | 0/1 | - | - | 0/1 | - | - | ||
| ADIPOQ IVS1+244G>A | ||||||||
| GG | 455/484 | 1.00 | 1.00 | 402/448 | 1.00 | 1.00 | ||
| AG | 470/523 | 1.00 (0.83–1.21) | 0.98 (0.79–1.22) | 0.88 | 408/453 | 1.05 (0.86–1.28) | 1.01 (0.81–1.27) | 0.92 |
| AA | 128/118 | 1.26 (0.93–1.69) | 1.15 (0.82–1.61) | 0.43 | 104/96 | 1.31 (0.95–1.81) | 1.22 (0.85–1.76) | 0.28 |
| ADIPOQ Ex2+53T>G | ||||||||
| TT | 834/877 | 1.00 | 1.00 | 722/775 | 1.00 | 1.00 | ||
| GT | 201/229 | 0.94 (0.75–1.17) | 0.91 (0.70–1.17) | 0.45 | 178/207 | 0.91 (0.72–1.15) | 0.86 (0.66–1.12) | 0.27 |
| GG | 16/19 | 0.71 (0.35–1.48) | 0.74 (0.32–1.74) | 0.50 | 12/15 | 0.77 (0.35–1.70) | 0.6 (0.25–1.47) | 0.27 |
| ADIPOQ IVS1−4514C>T | ||||||||
| CC | 573/624 | 1.00 | 1.00 | 513/573 | 1.00 | 1.00 | ||
| CT | 405/426 | 1.07 (0.88–1.29) | 1.05 (0.85–1.30) | 0.63 | 344/363 | 1.09 (0.90–1.33) | 1.08 (0.87–1.36) | 0.48 |
| TT | 64/70 | 1.00 (0.69–1.46) | 0.95 (0.62–1.46) | 0.82 | 46/59 | 0.90 (0.59–1.37) | 0.89 (0.56–1.42) | 0.62 |
| FTO IVS1−40478T>A | ||||||||
| TT | 387/424 | 1.00 | 1.00 | 321/355 | 1.00 | 1.00 | ||
| AT | 505/546 | 1.03 (0.85–1.26) | 0.98 (0.78–1.23) | 0.86 | 449/499 | 0.99 (0.8–1.21) | 0.99 (0.78–1.25) | 0.91 |
| AA | 171/172 | 1.18 (0.90–1.54) | 1.02 (0.76–1.38) | 0.87 | 151/160 | 1.10(0.83–1.45) | 1.00 (0.73–1.38) | 0.98 |
| FTO IVS1−27777C>A | ||||||||
| CC | 375/428 | 1.00 | 1.00 | 330/366 | 1.00 | 1.00 | ||
| AC | 504/533 | 1.06 (0.87–1.29) | 1.03 (0.83–1.29) | 0.78 | 436/479 | 1.00(0.81–1.23) | 1.01 (0.80–1.28) | 0.94 |
| AA | 176/166 | 1.18 (0.90–1.54) | 1.02 (0.76–1.39) | 0.87 | 150/157 | 1.04 (0.79–1.38) | 0.91 (0.66–1.25) | 0.56 |
| FTO IVS1−23525T>A | ||||||||
| TT | 386/436 | 1.00 | 1.00 | 339/375 | 1.00 | 1.00 | ||
| AT | 493/527 | 1.05 (0.87–1.28) | 1.05 (0.84–1.32) | 0.64 | 429/472 | 1.00 (0.81–1.23) | 1.03 (0.81–1.30) | 0.82 |
| AA | 174/167 | 1.16 (0.89–1.51) | 1.02 (0.76–1.38) | 0.88 | 147/155 | 1.05 (0.79–1.39) | 0.92 (0.67–1.26) | 0.60 |
AOR: adjusted odds ratio; 95% CI: 95% confidence interval.
a
OR was adjusted for sex, age (continuous), race, education, smoking, alcohol, history of diabetes, and family history of cancer.
b
with further adjustment for BMI.
**
Significant after adjusting for multiple comparisons.