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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Drug Alcohol Depend. 2010 Dec 4;115(1-2):150–155. doi: 10.1016/j.drugalcdep.2010.11.005

Figure 1. Time- and dose-related changes in drug effects.

Figure 1

(A) Subject-rated drug strength (reported at 2-minute intervals) as a function of time (pre-drug baseline to 60 minutes following inhalation). Data points show mean ratings (N=4). For graphical clarity, alternating doses in the dose sequence were deleted.

(B) Subject-rated peak drug strength from the end-of-session ratings as a function of dose (logarithmic abscissa). Data points show mean ratings (N=4); brackets show + and −1 SEM. Filled symbols indicate that the data point was significantly different from placebo (Tukey’s HSD test, p<.05).

(C) Peak heart rate (beats per minute) and blood pressure (mm of Hg) as a function of dose (logarithmic abscissa). Data points show means (N=4); brackets show + and − 1 SEM.